Clofazimine as a Treatment for Multidrug-Resistant Tuberculosis: A Review

Multidrug-resistant tuberculosis (MDR-TB) is an infectious disease caused by Mycobacterium which resistant to at least isoniazid and rifampicin. This a worldwide threat complicates the control of (TB). Long treatment duration, combination several drugs, adverse effects these drugs are factors that play role in poor outcomes MDR-TB patients. There have been many studies with repurposed improve outcomes, including clofazimine. Clofazimine recently moved from group 5 B used treat MDR-TB. drug belongs riminophenazine class, has lipophilic characteristics was previously discovered TB approved for leprosy. review discusses clofazimine as component patients MDR-TB, drug’s properties. In addition, we discuss efficacy, safety, tolerability treating study concludes clofazimine-containing regimen better efficacy compared standard one also well-tolerated. potential shorten duration treatment.